Moment-based fast discrete sine transforms

This paper presents a novel approach to compute discrete sine transforms (DSTs). By using a modular mapping, DSTs are approximated by the sum of a finite sequence of discrete moments. Hence, by extending our earlier technique in computing moments with an adder network only, DSTs can also be implemented easily by a systolic array primarily involving additions. The method can be applied to multidimensional DSTs as well as their inverses.published_or_final_versio

Cancer gene therapy targeting angiogenesis: An updated review

Since the relationship between angiogenesis and tumor growth was established by Folkman in 1971, scientists have made efforts exploring the possibilities in treating cancer by targeting angiogenesis. Inhibition of angiogenesis growth factors and administration of angiogenesis inhibitors are the basics of anti-angiogenesis therapy. Transfer of anti-angiogenesis genes has received attention recently not only because of the advancement of recombinant vectors, but also because of the localized and sustained expression of therapeutic gene product inside the tumor after gene transfer. This review provides the up-to-date information about the strategies and the vectors studied in the field of anti-angiogenesis cancer gene therapy. © 2006 The WJG Press. All rights reserved.published_or_final_versio

The interactive bending wrinkling behaviour of inflated beams

ArticleA model is proposed based on a Fourier series method to analyse the interactive bending wrinkling behaviour of inflated beams. The whole wrinkling evolution is tracked and divided into three stages by identifying the bifurcations of the equilibrium path. The critical wrinkling and failure moments of inflated beam are then able to be predicted. The global-local interactive buckling pattern is elucidated by the proposed theoretical model and also verified by non-contact experimental tests. The effects of geometric parameters, internal pressure and boundary conditions on the buckling of inflated beams are investigated in the end. Results reveal that the interactive buckling characteristics of inflated beam under bending are more sensitive to the dimensions of the structure and boundary conditions. We find that beams which are simply supported at both ends or clamped and simply supported boundary conditions may prevent the wrinkling formation. The results provide significant support for our understanding of the bending-wrinkling behaviour of inflated beams.This work is supported by National Natural Science Foundation of China, 11172079 and 11572099; Program for New Century Excellent Talents in University, NCET-11-0807; Natural Science Foundation of Heilongjiang Province of China, A2015002; the Fundamental Research Funds for the Central Universities, HIT.BRETIII.201209 and HIT.MKSTISP.2016 29

A novel approach to fast discrete Hartley transform

The Discrete Hartley transform (DHT) is an important tool in digital signal processing. We propose a novel approach to perform DHT. We transform DHT into a form expressed in discrete moments via a modular mapping and truncating Taylor series expansion and present a completely new formula for computing DHT. We extend the use of our systolic array for fast computation of moments without any multiplications, to one that computes DHT with only a few multiplications and without any evaluations of triangular functions. The multiplication number used in our method is O(Nlog2N/log2log2N) superior to O(Nlog 2N) in the conventional FDT. The execution time of the systolic array is only O(Nlog2N/log2log2N) for 1-D DHT and O(N k) for k-D DHT (k⩾2). The systolic array consists of very simple processing elements and hence it implies an easy and potential hardware/VLSI implementation. The approach is also applicable to DHT inverses.published_or_final_versio

PAK4 phosphorylates p53 at serine 215 to promote liver cancer metastasis

PAK4 kinase contributes to signaling pathways controlling cancer cell transformation, invasion and survival, but its clinicopathological impact has begun to emerge only recently. Here we report that PAK4 overexpression in hepatocellular carcinoma (HCC) conveys aggressive metastatic properties. A novel nuclear splice isoform of PAK4 lacking exon 2 sequences was isolated as part of our studies. By stably overexpressing or silencing PAK4 in HCC cells we showed that it was critical for their migration. Mechanistic investigations in this setting revealed that PAK4 directly phosphorylated p53 at S215, which not only attenuated transcriptional transactivation activity but also inhibited p53-mediated suppression of HCC cell invasion. Taken together, our results showed how PAK4 overexpression in HCC promotes metastatic invasion by regulating p53 phosphorylation.postprin

C-Reactive Protein Promotes Diabetic Kidney Disease in db/db Mice via the CD32b-Smad3-mTOR signaling Pathway

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Anomalies in the twist elastic behaviour of mixtures of calamitic and bent-core liquid crystals

The splay, twist and bend elastic constants (K11, K22 and K33) have been measured as a function of temperature in bent-core/calamitic mixtures based on three different calamitic materials (5CB, 8CB and ZLI1132) and two bent-core dopants. The behaviour of the splay and bend constants are as expected; a reduction in K33 of ~20%, in line with predictions from mixing rules and other observations. Interestingly, no change is seen in the splay constant, K11 of the calamitic hosts. Surprisingly though, the twist elastic constant exhibits a reduction of 30 – 40% in all mixtures across the nematic range, an effect not previously reported and much larger than mixing rules can explain. The elastic behaviour is universal in our mixtures. We explain part of the reduction in the twist deformation by considering the influence of the chiral conformer fluctuations of the bent-core molecules on the twist elastic constants of the mixtures. However, the dramatic reduction can only be fully explained by also including contributions from chiral conformer fluctuations of the calamitic host, a form of chiral amplification

Buckling behavior of carbon nanotubes under bending: from ripple to kink

This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record.This paper elucidates the buckling behavior of carbon nanotubes (CNTs) under bending. CNTs are modeled as continuous thin-wall circular tubes, and their buckling is governed by equations that take into account of the sectional Brazier effect and non-uniform structural deformation. The CNT governing equations (fourth-order ordinary differential nonlinear equations with integral conditions) are solved by introducing a continuation algorithm. In addition, the buckling behavior of CNTs under bending is simulated with objective molecular dynamics (OMD), and is used to verify the continuum results. We show that there exist low- and high-strain phases during the bending process of CNTs, and the transition in between may divide the whole bending process into three stages: low-curvature stage, mixed-curvature stage and high-curvature stage. Ripples are generated on the CNT surfaces before the formation of kinks. Compared to single-walled CNTs (SWCNTs), hydrogen-filled CNTs have a longer mixed-strain stage owing to the presence of internal pressure, and are therefore more inclined to exhibit a ripple morphology. Our results offer better understanding of the buckling behavior of CNTs, and may open up new opportunities for the design and applications of novel CNT-based nanoelectronics.National Natural Science Foundation of ChinaProgram for New Century 24 Excellent Talents in UniversityNatural Science Foundation of Heilongjiang Province of ChinaFundamental Research Funds for the Central Universitie

Quantum theory of light diffraction

At present, the theory of light diffraction only has the simple wave-optical approach. In this paper, we study light diffraction with the approach of relativistic quantum theory. We find that the slit length, slit width, slit thickness and wave-length of light have affected to the diffraction intensity and form of diffraction pattern. However, the effect of slit thickness on the diffraction pattern can not be explained by wave-optical approach, and it can be explained in quantum theory. We compare the theoretical results with single and multiple slits experiment data, and find the theoretical results are accordance with the experiment data. Otherwise, we give some theory prediction. We think all the new prediction will be tested by the light diffraction experiment.Comment: 10 page

Incremental prognostic value of global longitudinal strain in patients with type 2 diabetes mellitus

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